Below you can find the In the 1500s this paraguayan capital became spain's headquarters for its affairs in eastern south america Jeopardy Words Answer. The answer to In the 1500s this paraguayan capital became spain's headquarters for its affairs in eastern south america has 8 letters. This clue belongs to the World capitals category and is part of Jeopardy Word Level 2452. If you scroll near the bottom you will find other clues and answers part of level 2452